CD63 as an Activation-Linked T Cell Costimulatory Element

Costimulatory Element CD 63 as an Activation - Linked T Cell

Costimulatory Element CD 63 as an Activation - Linked T Cell and Walter Knapp

Costimulatory Element CD 63 as an Activation - Linked T Cell and

Costimulatory pathways of T-cell activation

T lymphocytes play an essential role in the defense against several pathogens and in tumor immune surveillance. However, T cells can also trigger autoimmune diseases and acute allograft rejection. Therefore, understanding the mechanisms of activation of T lymphocytes may help develop novel immunomodulators for therapeutic purposes. T-cell activation results from recognition by the T-cell recept...

Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF.

We recently reported that mast cells stimulated via FcepsilonRI aggregation can enhance T cell activation by a TNF-dependent mechanism. However, the molecular mechanisms responsible for such IgE-, Ag- (Ag-), and mast cell-dependent enhancement of T cell activation remain unknown. In this study we showed that mouse bone marrow-derived cultured mast cells express various costimulatory molecules, ...